Calorie restriction mimetics embody a rising analysis discipline directed towards growing therapies that mimic the anti-aging results of long-term calorie restriction with out requiring a change in consuming habits. A variety of approaches have been recognized that embody (1) intestinal inhibitors of fats and carbohydrate metabolism; (2) inhibitors of intracellular glycolysis; (3) stimulators of the AMPK pathway; (4) sirtuin activators; (5) inhibitors of the mTOR pathway, and (6) polyamines. A number of biotech firms have been fashioned to pursue a number of of those methods. The target of this evaluation is to explain the approaches directed towards glycolytic inhibition. This upstream technique is taken into account an efficient means to invoke a variety of anti-aging mechanisms induced by CR. Anti-cancer and anti-obesity results are necessary issues in early improvement efforts. Though many dozens of candidates may very well be mentioned, the compounds chosen to be reviewed are the next: 2-deoxyglucose, 3-bromopyruvate, chrysin, genistein, astragalin, resveratrol, glucosamine, mannoheptulose, and D-allulose. Some candidates have been investigated extensively with each constructive and destructive outcomes, whereas others are solely starting to be studied.
Laser therapies have introduced daybreak to refractory pores and skin ailments, but additionally had been accompanied by postlaser irritation and pores and skin barrier dysfunction. To recuperate pores and skin operate shortly, the analysis and improvement of energetic substances together with β-glucan for postlaser restore have attracted a lot consideration. To judge the efficacy and tolerance of skincare regimens containing β-glucan in repairing postlaser irritation and pores and skin barrier dysfunction after fractional laser remedy.
A complete of 20 sufferers with facial atrophic pimples scars who accepted fractional laser remedy had been recruited: 10 sufferers handled with ablative fractional CO2 laser and 10 sufferers handled with 1565nm nonablative fractional laser. Utilizing the tactic of split-face vehicle-control examine, the left half of the face was served because the remedy facet and accepted skincare regimens, and the best half was management facet accepted automobile. Noninvasive bioinstrumentation of pores and skin hydration index, transepidermal water loss (TEWL), and hemoglobin index (E worth) was detected within the examine. Normal digital images had been taken at every go to. The pores and skin tolerance and hostile impact had been additionally evaluated by topic questionnaire
“No Innovation With out Cooperation” – How Switzerland Innovation Promotes Cooperation Between Trade, Analysis and Startups
Switzerland Innovation, the Swiss innovation park with its 5 branches, is facilitating collaborations for firms, startups, and universities to search out options to among the world’s most urgent challenges within the fields of well being and the life sciences, particularly within the areas of chemistry, biochemistry, biomedicine, biotech, medtech and digital well being. Along with its quite a few and numerous companions, Switzerland Innovation creates an ecosystem for universities and analysis-based firms, accelerating the transformation of analysis outcomes into marketable services.
For over 50 years, Switzerland has been one of many main international locations driving innovation in biotechnology and its industrial functions. At the moment, some 1,000 biotech firms type a tightly knit, cross-functional community starting from analysis via to manufacturing. This community includes R&D firms, contract analysis organizations, and extremely specialised advisors and biotech traders. Collectively, they type an exterior innovation pool that enhances the in-house R&D capability of the big multi-national pharma firms. A extremely efficient startup framework, stable acceleration mechanisms, and revolutionary traders allow the emergence of a steady circulate of biotech startups that revitalize the trade with new applied sciences and merchandise supporting drug improvement and diagnostics.
Comparability of Industrial ELISA Kits to Verify the Absence of Transmission in Malaria Elimination Settings
Antimalarial antibody measurements are helpful as a result of they replicate historic and up to date publicity to malaria. As such, they could present further info to evaluate ongoing transmission in low endemic or pre-elimination settings the place instances are uncommon. As well as, the absence of antibody responses in sure people can point out the cessation of transmission. Industrial malaria enzyme-linked immunosorbent assays (ELISA) detect antimalarial antibodies and are generally used to display screen blood donations for attainable malaria an infection. Nonetheless, there is no such thing as a standardized take a look at to detect antimalarial antibodies for epidemiological use. Right here we in contrast 5 commercially obtainable ELISA kits (Trinity Biotech, newbio, DiaPro, Cellabs, and NovaTec) seeking a standardized software for supporting claims of absence of malaria transmission. For comparability, a analysis-based (RB) ELISA protocol was carried out alongside the industrial kits.
The industrial kits had been first in contrast utilizing serum samples from recognized malaria-unexposed people (n = 223) and Toxoplasma-infected people (n = 191) to evaluate specificity and cross-reactivity in opposition to non-malaria infections. As well as, 134 samples from ≥10-year-olds collected in a hyperendemic area within the Gambia within the early 1990s had been used to evaluate sensitivity. Three out of 5 kits confirmed excessive sensitivity (90-92%), excessive specificity (98-99%), low cross-reactivity (0-3%) and had been thought of user-friendly (Trinity Biotech, newbio and NovaTec).
Two of those kits (Trinity Biotech and NovaTec) had been taken ahead for epidemiological analysis and outcomes had been in comparison with these utilizing the RB-ELISA. Samples from two pre-elimination settings (Praia, Cape Verde; n = 1,396, and Bataan, the Philippines; n = 1,824) had been examined. Serological outcomes from each the Trinity Biotech package and the RB-ELISA concurred with latest passively detected case counts in each settings. Outcomes from the Trinity Biotech package mirrored a big lower within the variety of reported instances in Bataan within the 1990s higher than the RB-ELISA. Outcomes from the NovaTec package didn’t replicate transmission patterns in both setting.
Shaking Incubator 71L - EACH |
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| 6754 | Scientific Laboratory Supplies | EACH | EUR 7049.7 |
Benchtop Incubator Sts - 6L - EACH |
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| INC2028 | Scientific Laboratory Supplies | EACH | EUR 1506.6 |
Benchtop Incubator Sts - 18L - EACH |
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| INC2030 | Scientific Laboratory Supplies | EACH | EUR 1591.65 |
Benchtop Incubator Sts - 30L - EACH |
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| INC2032 | Scientific Laboratory Supplies | EACH | EUR 1567.35 |
Benchtop Incubator Sts - 40L - EACH |
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| INC2034 | Scientific Laboratory Supplies | EACH | EUR 1715.85 |
Benchtop Incubator Sts - 50L - EACH |
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| INC2036 | Scientific Laboratory Supplies | EACH | EUR 1836 |
Benchtop Incubator Sts - 75L - EACH |
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| INC2038 | Scientific Laboratory Supplies | EACH | EUR 2050.65 |
Benchtop Incubator Sts - 100L - EACH |
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| INC2040 | Scientific Laboratory Supplies | EACH | EUR 2263.95 |
Benchtop Incubator Sts - 125L - EACH |
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| INC2042 | Scientific Laboratory Supplies | EACH | EUR 2289.6 |
Benchtop Incubator Sts - 150L - EACH |
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| INC2044 | Scientific Laboratory Supplies | EACH | EUR 2254.5 |
Benchtop Incubator Sts - 200L - EACH |
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| INC2046 | Scientific Laboratory Supplies | EACH | EUR 3264.3 |
Benchtop Incubator CLAD - 18L - EACH |
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| INC2010 | Scientific Laboratory Supplies | EACH | EUR 1502.55 |
Benchtop Incubator CLAD - 30L - EACH |
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| INC2012 | Scientific Laboratory Supplies | EACH | EUR 1591.65 |
Benchtop Incubator CLAD - 40L - EACH |
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| INC2014 | Scientific Laboratory Supplies | EACH | EUR 1594.35 |
Benchtop Incubator CLAD - 50L - EACH |
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| INC2016 | Scientific Laboratory Supplies | EACH | EUR 1699.65 |
Benchtop Incubator CLAD - 75L - EACH |
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| INC2018 | Scientific Laboratory Supplies | EACH | EUR 1895.4 |
Benchtop Incubator CLAD - 100L - EACH |
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| INC2020 | Scientific Laboratory Supplies | EACH | EUR 2091.15 |
Benchtop Incubator CLAD - 121L - EACH |
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| INC2022 | Scientific Laboratory Supplies | EACH | EUR 2288.25 |
Benchtop Incubator CLAD - 150L - EACH |
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| INC2024 | Scientific Laboratory Supplies | EACH | EUR 2312.55 |
Benchtop Incubator CLAD - 200L - EACH |
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| INC2026 | Scientific Laboratory Supplies | EACH | EUR 2949.75 |
IKA KS4000i Shaking Incubator - EACH |
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| SHA2600 | Scientific Laboratory Supplies | EACH | EUR 9782.1 |
Benchtop Incubator CLAD +5 to 70 - EACH |
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| INC2008 | Scientific Laboratory Supplies | EACH | EUR 1428.3 |
Mini Shaking Incubator (base unit only) |
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| MSI-300 | Avans Biotechnology Corp | each | EUR 2000 |
Genorise® INC-C-2 Shaking Incubator |
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| GR146003 | Genorise Scientific | - | Ask for price |
Corning Petri Dish Shelf for Shaking Incubator 6791 - EACH |
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| 480145 | Scientific Laboratory Supplies | EACH | EUR 164.7 |
Corning Plastic Clamp 1L for Shaking Incubator 6791 - EACH |
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| 480152 | Scientific Laboratory Supplies | EACH | EUR 68.85 |
Corning Plastic Clamp 125mL for Shaking Incubator 6791 - EACH |
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| 480149 | Scientific Laboratory Supplies | EACH | EUR 55.35 |
Corning Plastic Clamp 250mL for Shaking Incubator 6791 - EACH |
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| 480150 | Scientific Laboratory Supplies | EACH | EUR 58.05 |
Corning Plastic Clamp 500mL for Shaking Incubator 6791 - EACH |
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| 480151 | Scientific Laboratory Supplies | EACH | EUR 66.15 |
IKA KS4000ic Shaking Incubator With Inbuilt Cooler - EACH |
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| SHA2610 | Scientific Laboratory Supplies | EACH | EUR 11399.4 |
Corning Sticky Mat 150 x 150 x 30mm for Shaking Incubator 6791 - EACH |
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| 480146 | Scientific Laboratory Supplies | EACH | EUR 81 |
Corning Universal Platform 30 x 30cm for Shaking Incubator 6791 - EACH |
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| 480144 | Scientific Laboratory Supplies | EACH | EUR 380.7 |
Shaker 10LR with non-slip rubber mat, Refrigerated Shaking Incubator, 115V |
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| BCM1628 | Bio Basic | 1 pcs, 1 UNIT | EUR 12299.57 |
Corning Microtiter Hotel for 4x Microplates for Shaking Incubator 6791 - EACH |
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| 480147 | Scientific Laboratory Supplies | EACH | EUR 280.8 |
Corning Combination Tube Holder 6x 15/50mL Tubes for Shaking Incubator 6791 - EACH |
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| 480148 | Scientific Laboratory Supplies | EACH | EUR 413.1 |
Incu-Shaker™ 10LR with non-slip rubber mat, Refrigerated Shaking Incubator, 115V |
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| H2012 | Benchmark Scientific | 1 each | EUR 10596.02 |
Incu-Shaker™ 10LR with non-slip rubber mat, Refrigerated Shaking Incubator, 230V |
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| H2012-E | Benchmark Scientific | 1 each | EUR 10596.02 |
AgileWasher TM Microplate Washer (built-in incubator with shaking function) |
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| AMPW-900 | Avans Biotechnology Corp | each | EUR 3500 |
AgileReader TM Microplate ELISA Reader (including 405,450,490,600nm filters)(built-in incubator with shaking function) |
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| AMPR-900-A | Avans Biotechnology Corp | each | EUR 4500 |
ELISA Microplate Shaker & incubator (holds 2, 96 well plate; room temp-40oC; 575-1500 rpm shaking; digital timer, compact) |
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| MPS-800 | Alpha Diagnostics | 1 | EUR 2910 |
AgileReader TM Microplate ELISA Reader (including 340, 405, 450, 490, 600nm filters)(built-in incubator with shaking function) |
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| AMPR-900-B | Avans Biotechnology Corp | each | EUR 5000 |
ELISA Microplate thermoshaker & incubator (holds 2, 96 well plate; room temp to 60oC; 250-1200 rpm shaking; digital timer, compact) |
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| MPS-802 | Alpha Diagnostics | 1 | EUR 3640.8 |
ELISA Microplate thermoshaker & incubator (holds 4, 96 well plate; room temp to 60oC; 250-1200 rpm shaking; digital timer, compact) |
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| MPS-804 | Alpha Diagnostics | 1 | EUR 4371.6 |
Incu-Shaker 10LR w n-slip mat Refrigerated Shakin Incubator 230V - EACH |
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| MIX7144 | Scientific Laboratory Supplies | EACH | EUR 15028.2 |
Incubation shaker, shaking movement 20mm orbital, Heating Range 4 - 60°C |
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| IS-OS30 | Phoenix instrument | each | EUR 6910 |
Incubation shaker, shaking movement 20mm orbital, Heating Range RT+5 -60°C |
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| IS-OS20 | Phoenix instrument | each | EUR 3310 |
Benchmark SureTemp Dual Convection Incubator 130L - EACH |
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| INC1502 | Scientific Laboratory Supplies | EACH | EUR 4900.5 |
Benchmark SureTemp Dual Convection Incubator 40L - EACH |
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| INC1500 | Scientific Laboratory Supplies | EACH | EUR 2852.55 |
Benchmark SureTemp Dual Convection Incubator 70L - EACH |
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| INC1501 | Scientific Laboratory Supplies | EACH | EUR 3676.05 |
115L Incubator Shaker Cooled - EACH |
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| SHA3008 | Scientific Laboratory Supplies | EACH | EUR 11207.7 |
NBS Shaker Incubator Classic E24 - EACH |
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| SHA4306 | Scientific Laboratory Supplies | EACH | EUR 9999.45 |
NBS Shaker Incubator Classic E25 - EACH |
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| SHA4308 | Scientific Laboratory Supplies | EACH | EUR 17298.06 |
NBS Shaker Incubator Classic E24R - EACH |
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| SHA4307 | Scientific Laboratory Supplies | EACH | EUR 13629.6 |
NBS Shaker Incubator Classic E25R - EACH |
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| SHA4310 | Scientific Laboratory Supplies | EACH | EUR 20777.64 |
KS 3000 i control incubator shaker - EACH |
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| SHA2590 | Scientific Laboratory Supplies | EACH | EUR 7804.35 |
115L Incubator Shaker SI-200D-L - EACH |
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| SHA3006 | Scientific Laboratory Supplies | EACH | EUR 9375.75 |
Cole-Parmer Stuart Incubator Shaker - EACH |
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| SHA3010 | Scientific Laboratory Supplies | EACH | EUR 7076.7 |
NBS Shaker Incubator Innova 44 25mm Orbit - EACH |
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| SHA1100 | Scientific Laboratory Supplies | EACH | EUR 21193.65 |
NBS Shaker Incubator Innova 44 51mm Orbit - EACH |
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| SHA1102 | Scientific Laboratory Supplies | EACH | EUR 21193.65 |
NBS Shaker Incubator Innova 43 25mm Orbit - EACH |
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| SHA4100 | Scientific Laboratory Supplies | EACH | EUR 21720.15 |
NBS Shaker Incubator Innova 43 51mm Orbit - EACH |
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| SHA4101 | Scientific Laboratory Supplies | EACH | EUR 21720.15 |
NBS Shaker Incubator Innova 40 25mm Orbit - EACH |
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| SHA4130 | Scientific Laboratory Supplies | EACH | EUR 12968.1 |
NBS Shaker Incubator Innova 40 19mm Orbit - EACH |
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| SHA4131 | Scientific Laboratory Supplies | EACH | EUR 12968.1 |
NBS Shaker Incubator Innova 42 25mm Orbit - EACH |
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| SHA4134 | Scientific Laboratory Supplies | EACH | EUR 15063.3 |
NBS Shaker Incubator Innova 42 19mm Orbit - EACH |
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| SHA4135 | Scientific Laboratory Supplies | EACH | EUR 15063.3 |
NBS Shaker Incubator Innova 44R 25mm Orbit - EACH |
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| SHA1104 | Scientific Laboratory Supplies | EACH | EUR 26064.45 |
NBS Shaker Incubator Innova 44R 51mm Orbit - EACH |
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| SHA1106 | Scientific Laboratory Supplies | EACH | EUR 26064.45 |
NBS Shaker Incubator Innova 43R 25mm Orbit - EACH |
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| SHA4110 | Scientific Laboratory Supplies | EACH | EUR 24633.45 |
NBS Shaker Incubator Innova 43R 51mm Orbit - EACH |
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| SHA4111 | Scientific Laboratory Supplies | EACH | EUR 24633.45 |
NBS Shaker Incubator Innova 40R 25mm Orbit - EACH |
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| SHA4132 | Scientific Laboratory Supplies | EACH | EUR 15210.45 |
NBS Shaker Incubator Innova 40R 19mm Orbit - EACH |
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| SHA4133 | Scientific Laboratory Supplies | EACH | EUR 15210.45 |
NBS Shaker Incubator Innova 42R 19mm Orbit - EACH |
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| SHA4139 | Scientific Laboratory Supplies | EACH | EUR 17107.2 |
NBS Shaker Incubator Innova 42R 25mm Orbit - EACH |
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| SHA4140 | Scientific Laboratory Supplies | EACH | EUR 17107.2 |
Stacking kit for S41i CO2 incubator shaker - EACH |
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| SHA4446 | Scientific Laboratory Supplies | EACH | EUR 1587.6 |
Additional shelf for S41i CO2 incubator shaker - EACH |
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| SHA4448 | Scientific Laboratory Supplies | EACH | EUR 328.05 |
Bench Top Shaker base, with built-in shaking head and six knobs. Glassware holders not included. 2-125rpm, 120V |
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| 099AS60012 | Glascol | each | EUR 2583 |
Bench Top Shaker base, with built-in shaking head and six knobs. Glassware holders not included. 2-125rpm, 240V |
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| 099AS60024 | Glascol | each | EUR 2613 |
New Brunswick S41i Biological CO2 Incubator Shaker - EACH |
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| SHA4430 | Scientific Laboratory Supplies | EACH | EUR 20147.53 |
Bench Top Shaker base, with built-in shaking head and six knobs. Glassware holders not included. 2-125rpm, 240V, CE |
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| 099AS60024CE | Glascol | each | EUR 2724 |
Universal platform for New Brunswick incubator shakers - EACH |
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| SHA4432 | Scientific Laboratory Supplies | EACH | EUR 988.2 |
CO2 Incubator, 150 L |
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| Q5103 | ABM | 1 | EUR 16500 |
Incubator IN30 - EACH |
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| INC8138 | Scientific Laboratory Supplies | EACH | EUR 1960.2 |
Incubator IN55 - EACH |
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| INC8140 | Scientific Laboratory Supplies | EACH | EUR 2442.15 |
Incubator IN75 - EACH |
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| INC8142 | Scientific Laboratory Supplies | EACH | EUR 2427.3 |
Incubator IF30 - EACH |
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| INC8170 | Scientific Laboratory Supplies | EACH | EUR 2332.8 |
Incubator IF55 - EACH |
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| INC8172 | Scientific Laboratory Supplies | EACH | EUR 2706.75 |
Incubator IF75 - EACH |
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| INC8174 | Scientific Laboratory Supplies | EACH | EUR 3335.85 |
Incubator IN110 - EACH |
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| INC8144 | Scientific Laboratory Supplies | EACH | EUR 2862 |
Incubator IN260 - EACH |
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| INC8148 | Scientific Laboratory Supplies | EACH | EUR 5073.3 |
Incubator IN450 - EACH |
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| INC8150 | Scientific Laboratory Supplies | EACH | EUR 6704.1 |
Incubator IN750 - EACH |
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| INC8152 | Scientific Laboratory Supplies | EACH | EUR 8896.5 |
Incubator IF110 - EACH |
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| INC8176 | Scientific Laboratory Supplies | EACH | EUR 3661.2 |
Incubator IF160 - EACH |
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| INC8178 | Scientific Laboratory Supplies | EACH | EUR 4496.85 |
Incubator IF260 - EACH |
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| INC8180 | Scientific Laboratory Supplies | EACH | EUR 5840.1 |
Incubator IF450 - EACH |
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| INC8182 | Scientific Laboratory Supplies | EACH | EUR 7519.5 |
Incubator IF750 - EACH |
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| INC8184 | Scientific Laboratory Supplies | EACH | EUR 9680.85 |
UVP Incubator, 230V UK + EU |
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| AJ95-0358-02 | Westburg | each | EUR 3498.9 |
KS 3000 ic control incubator shaker with built-in cooling spiral - EACH |
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| SHA2592 | Scientific Laboratory Supplies | EACH | EUR 9367.65 |
SureTherm CO2 Incubator, 180L |
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| H3565-180 | Benchmark Scientific | 1 each | EUR 7470.8 |
Crystal Growth Incubator 285L |
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| M-CI-IS26SD/PC | MiTeGen | 1 UNIT | EUR 7175 |
|
Description: Crystal Growth Incubator 285L |
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Crystal Growth Incubator 680L |
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| M-CI-IS28SSD/PC | MiTeGen | 1 UNIT | EUR 7885 |
|
Description: Crystal Growth Incubator 680L |
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Crystal Growth Incubator 765L |
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| M-CI-IS33SD/PC | MiTeGen | 1 UNIT | EUR 8960 |
|
Description: Crystal Growth Incubator 765L |
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Incubator IN30plus - EACH |
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| INC8154 | Scientific Laboratory Supplies | EACH | EUR 2771.55 |
Incubator IN55plus - EACH |
|||
| INC8156 | Scientific Laboratory Supplies | EACH | EUR 3125.25 |
Incubator IN75plus - EACH |
|||
| INC8158 | Scientific Laboratory Supplies | EACH | EUR 3527.55 |
Incubator IF30plus - EACH |
|||
| INC8186 | Scientific Laboratory Supplies | EACH | EUR 2982.15 |
Incubator IF55plus - EACH |
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| INC8188 | Scientific Laboratory Supplies | EACH | EUR 3562.65 |
Incubator IF75plus - EACH |
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| INC8190 | Scientific Laboratory Supplies | EACH | EUR 4012.2 |
Immunofluorescence Incubator |
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| FIA-101 | CTK Biotech | each | EUR 5335 |
Incubator IN110plus - EACH |
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| INC8160 | Scientific Laboratory Supplies | EACH | EUR 3960.9 |
Incubator IN160plus - EACH |
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| INC8162 | Scientific Laboratory Supplies | EACH | EUR 4941 |
Incubator IN260plus - EACH |
|||
| INC8164 | Scientific Laboratory Supplies | EACH | EUR 6018.3 |
Incubator IN450plus - EACH |
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| INC8166 | Scientific Laboratory Supplies | EACH | EUR 7824.6 |
Incubator IN750plus - EACH |
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| INC8168 | Scientific Laboratory Supplies | EACH | EUR 10066.95 |
Incubator IF110plus - EACH |
|||
| INC8192 | Scientific Laboratory Supplies | EACH | EUR 4517.1 |
Incubator IF160plus - EACH |
|||
| INC8194 | Scientific Laboratory Supplies | EACH | EUR 5629.5 |
Incubator IF260plus - EACH |
|||
| INC8196 | Scientific Laboratory Supplies | EACH | EUR 6808.05 |
Incubator IF450plus - EACH |
|||
| INC8198 | Scientific Laboratory Supplies | EACH | EUR 8718.3 |
Incubator IF750plus - EACH |
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| INC8200 | Scientific Laboratory Supplies | EACH | EUR 11206.35 |
1L Erlenmeyer flask platform with 11 clamps for NBS incubator shakers - EACH |
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| SHA4438 | Scientific Laboratory Supplies | EACH | EUR 978.75 |
2L Erlenmeyer flask platform with 6 clamps for NBS incubator shakers - EACH |
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| SHA4440 | Scientific Laboratory Supplies | EACH | EUR 1031.4 |
2.8L Erlenmeyer flask platform with 3 clamps for NBS incubator shakers - EACH |
|||
| SHA4442 | Scientific Laboratory Supplies | EACH | EUR 1031.4 |
4L Erlenmeyer flask platform with 3 clamps for NBS incubator shakers - EACH |
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| SHA4444 | Scientific Laboratory Supplies | EACH | EUR 1031.4 |
SureTherm CO2 Incubator, 180L, 230V |
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| H3565-180-E | Benchmark Scientific | each | EUR 7470.8 |
Binder BD115 Incubator 115L - EACH |
|||
| INC3004 | Scientific Laboratory Supplies | EACH | EUR 2693.78 |
Binder BD400 Incubator 400L - EACH |
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| INC3008 | Scientific Laboratory Supplies | EACH | EUR 6527.35 |
The Trinity Biotech industrial ELISA package was thought of dependable for epidemiological use and precisely described transmission patterns in two (beforehand) malaria endemic settings. Using this straightforward and standardized serological software could support nationwide management and elimination packages by confirming that areas are free from malaria.