Rising drug spending has led to elevated calls to curtail drug prices. Nonetheless, it’s unclear the place to focus on coverage options. We estimated extra returns (the extent to which a agency’s income are larger than anticipated given the chance related to their investments) for producers and middlemen within the pharmaceutical provide chain to find out who’s making extreme income. Extra returns had been calculated because the distinction between return on invested capital and the anticipated returns given threat, which is named the weighted common value of capital.
We in contrast extra returns for producers and middlemen to the typical for S&P 500 corporations. We discover that each producers and middlemen have larger extra returns in 2013-2018 in contrast with the S&P 500. Nonetheless, if we deal with analysis and improvement (R&D) as an funding fairly than an expense, we discover that extra returns for pharmaceutical producers are decrease than the S&P 500 (1.7% vs. 3.6%), however biotech producers (9.6%), wholesalers (8.1%), and insurers/PBM/retailers (5.9%) proceed to have considerably larger extra returns in comparison with the S&P 500. Our findings counsel public insurance policies that promote competitors in all areas of the pharmaceutical provide chain are essential avenues for curbing drug spending.
An ASCO Activity Pressure was convened to evaluate the particular burdens and challenges with FAs and to develop suggestions to enhance their efficiencies and effectiveness. Stakeholders (together with trial websites, biotech-pharma sponsors, and CROs) supplied insights into challenges and provided options via two surveys and an in-person assembly. The Activity Pressure used the suggestions to formulate consensus suggestions to enhance FAs for oncology scientific trials.
Three key suggestions had been recognized for utility throughout all biotech-pharma sponsored trials: (1) implement a streamlined and uniform FA course of throughout trials and sponsors; (2) decrease and standardize questions; and (3) leverage know-how to centralize FAs, facilitate communications, and cut back redundancies.
There may be an urgency to enhance the present FA course of, which is dear, inconsistent, inefficient, labor intensive, and of unsure effectiveness. All stakeholders stand to learn from implementing these suggestions, which goal to reduce burdens and be certain that extra trial websites and sufferers have well timed entry to oncology scientific trials. To have significant impression, adoption and constant execution of those suggestions throughout all trials, sponsors, CROs, and websites are important.
Creating and sustaining collaborative multi-institutional business website go to packages: a toolkit
As extra early profession scientists enter into various profession pathways, visiting native corporations or organizations can assist their exploration of those paths. As an environment friendly technique to facilitate this, we developed a collaborative regional website go to program: the Enhancing Native Trade Transitions via Exploration (ELITE) Consortium. Consortium members prepare half-day visits to native business websites, thus offering corporations and trainees the chance to fulfill and establish potential skilled and profession alternatives.
Three completely different coaching establishments labored cooperatively within the improvement and upkeep of this system. The ELITE Consortium was developed with eight phased steps; tips and working procedures had been created for every of those steps and are supplied together with pattern supplies for establishments curious about constructing related packages.
Prior to totally growing this system, trainee pursuits had been evaluated through questionnaire. Throughout program implementation and thereafter, program administrators tracked attendance and picked up profession consequence information from publicly accessible sources to establish first job positions after coaching. Regression analyses and chi-squared analyses had been used to look at website go to matches and profession consequence information. Analyses counsel a constructive impression of website visits on postdoctoral and graduate trainees’ profession outcomes at corporations or establishments that match an identical sector (e.g., for-profit) and kind (e.g., biotech, pharmaceutical, contract analysis group). Regardless of a small pattern dimension, proof suggests an particularly constructive impression on trainees who arrange website visits to corporations in contrast with those that merely take part.
The ELITE Consortium was profitable in serving to trainees discover and establish a mess of profession paths. Trainees attained employment both straight or in associated corporations and establishments visited by ELITE members. The joint, three-institution, versatile nature of the ELITE Consortium positively impacts this system’s sustainability and attain. The toolkit supplied right here will assist different establishments to duplicate and adapt this system with minimal effort.
How one can construct a well-rounded CV and get employed after your PhD
Embarking on a PhD offers many alternatives for private {and professional} improvement past scientific analysis. This instalment of the Phrases of Recommendation sequence goals to offer steerage and recommendations on harnessing these assets to construct a well-rounded CV and enhance your possibilities of getting employed after your PhD. We offer two views on growing your CV to optimise profession alternatives in academia and past. The primary perspective is by Dr Zheng-Shan Chong, a post-doctoral analysiser in Singapore, and focuses on the acquisition of a variety of expertise and expertise that might open doorways to a profession outdoors of academia.
Past her day job, Shan manages an article sequence on bioentrepreneurship and profession improvement for Biotech Connection Singapore, which has allowed her to talk to a number of analysisers who’ve efficiently transitioned to non-analysis roles. Right here, she summarises the insights gained from these conversations. That is adopted by recommendation and ideas from Dr Sara Clohisey, a post-doctoral analysiser in Edinburgh who modified fields after her PhD, from Drosophila cell biology to human genetics and virology.
Galaxy 48R CO2 Incubator+O2 cont + h temp disinfection 48L 0.1-19% - EACH |
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| INC644062 | Scientific Laboratory Supplies | EACH | EUR 13180.05 |
Refrigerated Cooled Incubator Glass Door 150L - EACH |
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| RLCG01503 | Scientific Laboratory Supplies | EACH | EUR 5778 |
Refrigerated Cooled Incubator Glass Door 340L - EACH |
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| RLCG03401 | Scientific Laboratory Supplies | EACH | EUR 7040.25 |
Refrigerated Cooled Incubator Glass Door 570L - EACH |
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| RLCG0600 | Scientific Laboratory Supplies | EACH | EUR 12131.1 |
Galaxy 48 R CO2 Incubator with high-temperature disinfection 0.1-19 % O2 control and humidity alert and monitoring package - EACH |
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| INC6380 | Scientific Laboratory Supplies | EACH | EUR 15552 |
Inner Door Shelving Kit 4 Sets 2 Mini Shelves for an Esco CO2 incubator - EACH |
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| INC2096 | Scientific Laboratory Supplies | EACH | EUR 678.59 |
SureTherm CO2 Incubator, 180L with High heat Decontamination, Split Window Door and O2 control |
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| H3565-180HDO2 | Benchmark Scientific | 1 each | EUR 12844.62 |
SureTherm CO2 Incubator, 180L with High heat Decontamination, Split Window Door and O2 control, 230V |
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| H3565-180HDO2-E | Benchmark Scientific | each | EUR 12844.62 |
3 inner door option for all LEEC 190 L incubators - EACH |
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| INC3214 | Scientific Laboratory Supplies | EACH | EUR 1323 |
Digital Incubator S160D - EACH |
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| INC7210 | Scientific Laboratory Supplies | EACH | EUR 3636.9 |
Reversed Door Swing Option for Esco CO2 incubators - EACH |
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| INC2070 | Scientific Laboratory Supplies | EACH | EUR 198.29 |
48R incubator hi-temp O2 cont 2plit inner doors - EACH |
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| INC3019 | Scientific Laboratory Supplies | EACH | EUR 12263.4 |
Inner perspex door for LMS Incubators INC5010 5011 5012 5013 5014 5015 - EACH |
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| INC5050 | Scientific Laboratory Supplies | EACH | EUR 1029.63 |
CO2 Incubator, 150 L |
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| Q5103 | ABM | 1 | EUR 16500 |
Incubator IN30 - EACH |
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| INC8138 | Scientific Laboratory Supplies | EACH | EUR 1960.2 |
Incubator IN55 - EACH |
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| INC8140 | Scientific Laboratory Supplies | EACH | EUR 2442.15 |
Incubator IN75 - EACH |
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| INC8142 | Scientific Laboratory Supplies | EACH | EUR 2427.3 |
Incubator IF30 - EACH |
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| INC8170 | Scientific Laboratory Supplies | EACH | EUR 2332.8 |
Incubator IF55 - EACH |
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| INC8172 | Scientific Laboratory Supplies | EACH | EUR 2706.75 |
Incubator IF75 - EACH |
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| INC8174 | Scientific Laboratory Supplies | EACH | EUR 3335.85 |
Incubator IN110 - EACH |
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| INC8144 | Scientific Laboratory Supplies | EACH | EUR 2862 |
Incubator IN260 - EACH |
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| INC8148 | Scientific Laboratory Supplies | EACH | EUR 5073.3 |
Incubator IN450 - EACH |
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| INC8150 | Scientific Laboratory Supplies | EACH | EUR 6704.1 |
Incubator IN750 - EACH |
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| INC8152 | Scientific Laboratory Supplies | EACH | EUR 8896.5 |
Incubator IF110 - EACH |
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| INC8176 | Scientific Laboratory Supplies | EACH | EUR 3661.2 |
Incubator IF160 - EACH |
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| INC8178 | Scientific Laboratory Supplies | EACH | EUR 4496.85 |
Incubator IF260 - EACH |
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| INC8180 | Scientific Laboratory Supplies | EACH | EUR 5840.1 |
Incubator IF450 - EACH |
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| INC8182 | Scientific Laboratory Supplies | EACH | EUR 7519.5 |
Incubator IF750 - EACH |
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| INC8184 | Scientific Laboratory Supplies | EACH | EUR 9680.85 |
UVP Incubator, 230V UK + EU |
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| AJ95-0358-02 | Westburg | each | EUR 3498.9 |
Stacking kit for S41i CO2 incubator shaker - EACH |
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| SHA4446 | Scientific Laboratory Supplies | EACH | EUR 1587.6 |
SureTherm CO2 Incubator, 180L |
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| H3565-180 | Benchmark Scientific | 1 each | EUR 7470.8 |
Crystal Growth Incubator 285L |
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| M-CI-IS26SD/PC | MiTeGen | 1 UNIT | EUR 7175 |
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Description: Crystal Growth Incubator 285L |
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Crystal Growth Incubator 680L |
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| M-CI-IS28SSD/PC | MiTeGen | 1 UNIT | EUR 7885 |
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Description: Crystal Growth Incubator 680L |
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Crystal Growth Incubator 765L |
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| M-CI-IS33SD/PC | MiTeGen | 1 UNIT | EUR 8960 |
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Description: Crystal Growth Incubator 765L |
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Incubator IN30plus - EACH |
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| INC8154 | Scientific Laboratory Supplies | EACH | EUR 2771.55 |
Incubator IN55plus - EACH |
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| INC8156 | Scientific Laboratory Supplies | EACH | EUR 3125.25 |
Incubator IN75plus - EACH |
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| INC8158 | Scientific Laboratory Supplies | EACH | EUR 3527.55 |
Incubator IF30plus - EACH |
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| INC8186 | Scientific Laboratory Supplies | EACH | EUR 2982.15 |
Incubator IF55plus - EACH |
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| INC8188 | Scientific Laboratory Supplies | EACH | EUR 3562.65 |
Incubator IF75plus - EACH |
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| INC8190 | Scientific Laboratory Supplies | EACH | EUR 4012.2 |
Immunofluorescence Incubator |
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| FIA-101 | CTK Biotech | each | EUR 5335 |
Incubator IN110plus - EACH |
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| INC8160 | Scientific Laboratory Supplies | EACH | EUR 3960.9 |
Incubator IN160plus - EACH |
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| INC8162 | Scientific Laboratory Supplies | EACH | EUR 4941 |
Incubator IN260plus - EACH |
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| INC8164 | Scientific Laboratory Supplies | EACH | EUR 6018.3 |
Incubator IN450plus - EACH |
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| INC8166 | Scientific Laboratory Supplies | EACH | EUR 7824.6 |
Incubator IN750plus - EACH |
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| INC8168 | Scientific Laboratory Supplies | EACH | EUR 10066.95 |
Incubator IF110plus - EACH |
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| INC8192 | Scientific Laboratory Supplies | EACH | EUR 4517.1 |
Incubator IF160plus - EACH |
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| INC8194 | Scientific Laboratory Supplies | EACH | EUR 5629.5 |
Incubator IF260plus - EACH |
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| INC8196 | Scientific Laboratory Supplies | EACH | EUR 6808.05 |
Incubator IF450plus - EACH |
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| INC8198 | Scientific Laboratory Supplies | EACH | EUR 8718.3 |
Incubator IF750plus - EACH |
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| INC8200 | Scientific Laboratory Supplies | EACH | EUR 11206.35 |
UniPact? Shaking Incubator |
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| ACT-USI | ACTGene | each | EUR 5560.8 |
Additional shelf for S41i CO2 incubator shaker - EACH |
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| SHA4448 | Scientific Laboratory Supplies | EACH | EUR 328.05 |
SureTherm CO2 Incubator, 180L, 230V |
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| H3565-180-E | Benchmark Scientific | each | EUR 7470.8 |
Binder BD115 Incubator 115L - EACH |
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| INC3004 | Scientific Laboratory Supplies | EACH | EUR 2693.78 |
Binder BD400 Incubator 400L - EACH |
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| INC3008 | Scientific Laboratory Supplies | EACH | EUR 6527.35 |
SHAKING INCUBATOR, 49L, 120V |
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| 6750 | CORNING | 1/pk | EUR 4740 |
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Description: Lab Equipment; Constant Temperature Equipment |
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SHAKING INCUBATOR, 71L, 120V |
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| 6753 | CORNING | 1/pk | EUR 5392.8 |
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Description: Lab Equipment; Constant Temperature Equipment |
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Shaking Incubator 49L - EACH |
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| 6752 | Scientific Laboratory Supplies | EACH | EUR 6339.6 |
Shaking Incubator 71L - EACH |
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| 6754 | Scientific Laboratory Supplies | EACH | EUR 7049.7 |
ComfyTempTM Portable Incubator |
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| CTPI-300 | Avans Biotechnology Corp | each | EUR 1100 |
New Brunswick S41i Biological CO2 Incubator Shaker - EACH |
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| SHA4430 | Scientific Laboratory Supplies | EACH | EUR 20147.53 |
SureTherm CO2 Incubator, 45L |
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| H3565-45 | Benchmark Scientific | 1 each | EUR 6184.74 |
Incubator BD056-230V - EACH |
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| INC1015 | Scientific Laboratory Supplies | EACH | EUR 2001.97 |
Incubator BD260-230V - EACH |
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| INC1016 | Scientific Laboratory Supplies | EACH | EUR 4562.09 |
Incubator ED056-230V - EACH |
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| INC1017 | Scientific Laboratory Supplies | EACH | EUR 1887.41 |
Incubator BF056-230V - EACH |
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| INC1019 | Scientific Laboratory Supplies | EACH | EUR 2718.75 |
Incubator BF260-230V - EACH |
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| INC1021 | Scientific Laboratory Supplies | EACH | EUR 5525.63 |
LMS Incubator 120L Series 1A - EACH |
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| INC5302 | Scientific Laboratory Supplies | EACH | EUR 4691.25 |
LMS Incubator 201L Series 1A - EACH |
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| INC5304 | Scientific Laboratory Supplies | EACH | EUR 4981.5 |
LMS Incubator 272L Series 1A - EACH |
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| INC5306 | Scientific Laboratory Supplies | EACH | EUR 5134.05 |
Multipurpose Incubator 100C 250L - EACH |
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| INC2262 | Scientific Laboratory Supplies | EACH | EUR 6218.1 |
Multipurpose Incubator 100C 320L - EACH |
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| INC2264 | Scientific Laboratory Supplies | EACH | EUR 6551.55 |
Multipurpose Incubator 100C 450L - EACH |
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| INC2266 | Scientific Laboratory Supplies | EACH | EUR 8240.4 |
Multipurpose Incubator 100C 535L - EACH |
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| INC2268 | Scientific Laboratory Supplies | EACH | EUR 8924.85 |
Multipurpose Incubator 100C 645L - EACH |
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| INC2270 | Scientific Laboratory Supplies | EACH | EUR 12098.7 |
Multipurpose Incubator 100C 750L - EACH |
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| INC2272 | Scientific Laboratory Supplies | EACH | EUR 11040.3 |
Multipurpose Incubator 100C 865L - EACH |
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| INC2274 | Scientific Laboratory Supplies | EACH | EUR 13026.15 |
Compressor cooled Incubator -256 - EACH |
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| INC2400 | Scientific Laboratory Supplies | EACH | EUR 14040 |
Compressor cooled Incubator -449 - EACH |
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| INC2402 | Scientific Laboratory Supplies | EACH | EUR 17219.25 |
Compressor cooled Incubator -749 - EACH |
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| INC2404 | Scientific Laboratory Supplies | EACH | EUR 19620.9 |
Incubator Dipslide DI10 - EACH |
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| INC1012 | Scientific Laboratory Supplies | EACH | EUR 581.85 |
Mini Incubator for Test Kit |
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| M1005 | Ring Biotechnology Co | 1set | EUR 100 |
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Description: Instrument |
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92 L Cooled Incubator epoxy |
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| INC2156 | Scientific Laboratory Supplies | EACH | EUR 3954.66 |
Refrigerated Cooled Incubator 150L - EACH |
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| RLSD01503 | Scientific Laboratory Supplies | EACH | EUR 5335.2 |
Refrigerated Cooled Incubator 340L - EACH |
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| RLSD03401 | Scientific Laboratory Supplies | EACH | EUR 6309.9 |
Refrigerated Cooled Incubator 570L - EACH |
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| RLSD0600 | Scientific Laboratory Supplies | EACH | EUR 11853 |
LEEC C100 Classic Incubator 100L - EACH |
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| INC1900 | Scientific Laboratory Supplies | EACH | EUR 2980.8 |
BF115 Incubator Mech 115L - EACH |
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| INC3036 | Scientific Laboratory Supplies | EACH | EUR 3550.09 |
BF400 Incubator Mech 400L - EACH |
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| INC3038 | Scientific Laboratory Supplies | EACH | EUR 6904.83 |
BF720 Incubator Mech 720L - EACH |
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| INC3040 | Scientific Laboratory Supplies | EACH | EUR 9221.13 |
92 L Cooled Incubator St S |
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| INC2172 | Scientific Laboratory Supplies | EACH | EUR 4433.46 |
92 L Cooled Incubator St S |
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| INC2180 | Scientific Laboratory Supplies | EACH | EUR 4664.88 |
LMS Cooled Incubator 1200L Series 4 - EACH |
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| INC5022 | Scientific Laboratory Supplies | EACH | EUR 11637.3 |
Benchtop Incubator Sts - 6L - EACH |
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| INC2028 | Scientific Laboratory Supplies | EACH | EUR 1506.6 |
Binder BD23 Incubator 23L - EACH |
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| INC3000 | Scientific Laboratory Supplies | EACH | EUR 2065.13 |
294 L Cooled Incubator St S |
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| INC2176 | Scientific Laboratory Supplies | EACH | EUR 5515.32 |
516 L Cooled Incubator St S |
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| INC2178 | Scientific Laboratory Supplies | EACH | EUR 7348.44 |
294 L Cooled Incubator St S |
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| INC2184 | Scientific Laboratory Supplies | EACH | EUR 6184.5 |
516 L Cooled Incubator St S |
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| INC2186 | Scientific Laboratory Supplies | EACH | EUR 8099.7 |
SureTherm CO2 Incubator, 45L, 230V |
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| H3565-45-E | Benchmark Scientific | each | EUR 6184.74 |
Benchtop Incubator Sts - 18L - EACH |
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| INC2030 | Scientific Laboratory Supplies | EACH | EUR 1591.65 |
Benchtop Incubator Sts - 30L - EACH |
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| INC2032 | Scientific Laboratory Supplies | EACH | EUR 1567.35 |
Benchtop Incubator Sts - 40L - EACH |
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| INC2034 | Scientific Laboratory Supplies | EACH | EUR 1715.85 |
Benchtop Incubator Sts - 50L - EACH |
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| INC2036 | Scientific Laboratory Supplies | EACH | EUR 1836 |
Benchtop Incubator Sts - 75L - EACH |
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| INC2038 | Scientific Laboratory Supplies | EACH | EUR 2050.65 |
Benchtop Incubator Sts - 100L - EACH |
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| INC2040 | Scientific Laboratory Supplies | EACH | EUR 2263.95 |
Benchtop Incubator Sts - 125L - EACH |
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| INC2042 | Scientific Laboratory Supplies | EACH | EUR 2289.6 |
Benchtop Incubator Sts - 150L - EACH |
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| INC2044 | Scientific Laboratory Supplies | EACH | EUR 2254.5 |
Benchtop Incubator Sts - 200L - EACH |
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| INC2046 | Scientific Laboratory Supplies | EACH | EUR 3264.3 |
Benchtop Incubator CLAD - 18L - EACH |
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| INC2010 | Scientific Laboratory Supplies | EACH | EUR 1502.55 |
Benchtop Incubator CLAD - 30L - EACH |
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| INC2012 | Scientific Laboratory Supplies | EACH | EUR 1591.65 |
Benchtop Incubator CLAD - 40L - EACH |
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| INC2014 | Scientific Laboratory Supplies | EACH | EUR 1594.35 |
Benchtop Incubator CLAD - 50L - EACH |
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| INC2016 | Scientific Laboratory Supplies | EACH | EUR 1699.65 |
Benchtop Incubator CLAD - 75L - EACH |
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| INC2018 | Scientific Laboratory Supplies | EACH | EUR 1895.4 |
Benchtop Incubator CLAD - 100L - EACH |
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| INC2020 | Scientific Laboratory Supplies | EACH | EUR 2091.15 |
Benchtop Incubator CLAD - 121L - EACH |
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| INC2022 | Scientific Laboratory Supplies | EACH | EUR 2288.25 |
Benchtop Incubator CLAD - 150L - EACH |
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| INC2024 | Scientific Laboratory Supplies | EACH | EUR 2312.55 |
Benchtop Incubator CLAD - 200L - EACH |
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| INC2026 | Scientific Laboratory Supplies | EACH | EUR 2949.75 |
Though not fairly as dramatic as leaving academia utterly, this shift prompted her to rethink her strategy to writing a tutorial CV in order that it might enchantment to an employer from a unique area. Sara’s perspective is especially geared in direction of careers in analysis. We hope that these distinctive views from skilled people who’ve efficiently navigated the trail from graduate scholar to working scientist will show helpful to those that are planning their subsequent strikes after finishing a PhD.